Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetRyanodine receptor

Cell permeable: yes

General description

A skeletal muscle relaxant. Blocks intracellular calcium release from the sarcoplasmic reticulum during excitation-contraction coupling by binding to the ryanodine receptor. Blocks long-term depression and depotentiation.

A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor. Inhibits long-term depression and depotentiation of synaptic transmission. Has neuroprotective effects in cases of cerebral ischemia.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.O'Mara, S.M., et al. 1995. Neuroscience68, 621.Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem.270, 18465.Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA91, 3039.Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3039.

Packaging

100 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)